Clinical trials are always underway at Springfield Clinic, in a number of medical specialties. Not all new medicines work, and there is no way to know their effectiveness in treating or curing disease unless clinical trials are performed. To that end, the Clinical Research Department works closely with the pharmaceutical companies, who are pioneering the new treatments, to get involved with the most innovative and promising therapies that have the potential to benefit our patients.

If you are considering participating in a clinical trial, it may be because you are affected by a specific health condition or because a loved one is affected. To find out what opportunities might be available to your or your family members, please find a list of our current studies below and the medical condition, or “indication,” being studied. We invite you to check back frequently as we have many upcoming studies as well. You may also be interested in those studies that are now closed to enrollment, which can be found under studies in follow-up and completed studies.

Condition Principal Investigator Description
Ankylosing Spondylitis Robert Trapp, MD A study to compare Cosentyx 150mg vs. 300mg in adults with Ankylosing Spondylitis
Bone or Joint Infections Donald Graham, MD Open-label use of Oral Sodium Fusidate for treatment of Staph Bone or Joint Infections (age ≥ 12 years) for whom chronic antibiotic suppressive therapy is indicated (Enrollment Closed)
Breast Cancer Karen Hoelzer, MD Long-term follow up of women with Early-Stage HER-2/neu Overexpressed/Amplified Breast Cancer previously treated with Trastuzumab followed by Neratinib (IN FOLLOW UP)
C-difficile Steven O'Marro, MD A Phase 3 study of SER109 (Ecobiotic Drug) to reduce recurrence of C-diff infection in adults who have received antibiotic treatment for recurrent C-diff infection.
Diabetic Retinopathy Ramanath Bhandari, MD Intravitreous Anti-Vascular Endothelial Growth Factor Treatment for Prevention of Diabetic Retinopathy (Enrollment Closed)
Diabetes - Type 1 Rebecca Green, MD and Chaitanya Mamillapalli, MD A natural history study of the development of Type 1 Diabetes
Distal Tibial Fractures Matthew Gardner, MD Observational Study of Patients with Distal Tibial Fractures Requiring Surgical Intervention with Locked Plating
Diabetic Macular Edema Ramanath Bhandari, MD Aflibercept vs. Bevacizumab + Deferred Aflibercept for the Treatment of DME
Diabetes - Type 2 Sufyan Said, MD A study of cardiovascular safety of oral Semaglutide in adults with Type 2 Diabetes Mellitus (enrollment closed)
Flu/Pneumonia Vaccines Randy Western, MD Study of Safety and Effectiveness of V114 Pneumonia Vaccine with given with Quadrivalent Flu Vaccine in Healthy Adults 50yrs or older(enrollment closed)