Springfield Clinic’s physicians have conducted clinical trials for over 50 years across numerous medical specialties. To date, the Clinical Research Department has conducted more than 400 clinical trials and continues research activities today. Search the table below to review our current clinical trials, investigators and medical conditions under study.

Please contact us if you have additional questions about Springfield Clinic’s Clinical Research Department or current clinical trial activities.

Condition Principal Investigator Description
Cancer Preet Singh, MD (and Oncology Department) Members of Heartland NCORP Cancer Research
C-difficile Steven O'Marro, MD A Phase 3 study of SER109 (Ecobiotic Drug) to reduce recurrence of C-diff infection in adults who have received antibiotic treatment for recurrent C-diff infection.
Chronic Cough Renu Govindaiah, MD Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough
Colorectal Cancer Peter Hofmann, MD Prevention of Colorectal Cancer Through Multiomics Blood Testing.
Colorectal Cancer Peter Hofmann, MD Sample Collection for cfDNA diagnostic development
Diabetic Macular Edema Ramanath Bhandari, MD Aflibercept vs. Bevacizumab + Deferred Aflibercept for the Treatment of DME
Diabetic Macular Edema Ram Bhandari, MD A RANDOMIZED, DOUBLE-MASKED, ACTIVE-CONTROLLED PHASE 2/3 STUDY OF THE EFFICACY AND SAFETY OF HIGH-DOSE AFLIBERCEPT IN PATIENTS WITH DIABETIC MACULAR EDEMA.
Diabetic Retinopathy Ramanath Bhandari, MD Intravitreous Anti-Vascular Endothelial Growth Factor Treatment for Prevention of Diabetic Retinopathy (Enrollment Closed)
Healthcare Machine Learning Chaitanya Mamillapalli, MD Development and evaluation of a machine learning algorithm for prediction of clinical diagnosis
Kidney Transplant Brad West, MD APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)